Novel in vitro Cell Lung Cell Exposure System for
Traditionaldrugtestingmethod:
Inhalationdrugtestingmethod:
Submerged cell culture
Air-liquid interface cell culture
Medium
Medium
Physiologically realistic:
‐ Epithelial cells cultured atair‐
liquidinterface
‐
eroso
ze
rug app
cat
on
VITROCELLSystems,
Waldkirch,Germany
Highdrug‐cell delivery efficiency
Advantageso
the ALICE‐CLOUDsystem
http://www.vitrocell.com
Exact dosimetry
Shortexposure time
Easy‐to‐use
Compact:Operableunder clean‐bench conditions
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Preclinical Inhalation S
stem
Airway Pressure
Controller&Analysis
Exhalation
valve
Valves
Animal or
Artificial
Exhalation
LinearActuator
Inhalation
Pistonpump
Air
Cylinder Pressure
Nebulizer
Advantagesof COAALA‐MOUSEsystem over existing devices
‐
Allclinically relevantnebulizers can be used
Exact dosimetry
Shortexposure time
Easy‐to‐use
www.m4.de
Preclinical Inhalation S
stem
PhotoofCOAALA‐MOUSE
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Local Application of Proteasom Inhibitors does not
Histology
treatment
treatment
Bleo Bleo
+ONX
• Fibrotic markers (Collagen-1 mRNA) did not respond on proteasome
inhibitors (ONX0912)
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