AEG Electrolux COMPETENCE 5133 V User Manual Page 51

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Novel in vitro Cell Lung Cell Exposure System for
POC Studies
with
Inhalation Products
POC
Studies
with
Inhalation
Products
Traditionaldrugtestingmethod:
Inhalationdrugtestingmethod:
Submerged cell culture
Aerosol
Air-liquid interface cell culture
Aerosol
Medium
Medium
Physiologically realistic:
Epithelial cells cultured atair
liquidinterface
Alid
d
li i
A
eroso
li
ze
d
d
rug app
li
cat
i
on
VITROCELLSystems,
Waldkirch,Germany
Highdrugcell delivery efficiency
Clinically
relevance
Advantageso
f
the ALICECLOUDsystem
http://www.vitrocell.com
Clinically
relevance
Exact dosimetry
Shortexposure time
Easytouse
Compact:Operableunder cleanbench conditions
www.m4.de
Preclinical Inhalation S
y
stem
y
Airway Pressure
Controller&Analysis
Exhalation
valve
Valves
Animal or
Artificial
Lung
Exhalation
Lung
LinearActuator
Inhalation
Pistonpump
Air
Cylinder Pressure
Nebulizer
High
drug
cell
delivery
efficiency
Advantagesof COAALAMOUSEsystem over existing devices
High
drug
cell
delivery
efficiency
Allclinically relevantnebulizers can be used
Exact dosimetry
Shortexposure time
Easytouse
www.m4.de
Preclinical Inhalation S
y
stem
y
PhotoofCOAALAMOUSE
www.m4.de
Local Application of Proteasom Inhibitors does not
alleviate
Experimental
Pulmonary
Fibrosis
alleviate
Experimental
Pulmonary
Fibrosis
Histology
treatment
treatment
Bleo Bleo
+ONX
Fibrotic markers (Collagen-1 mRNA) did not respond on proteasome
inhibitors (ONX0912)
www.m4.de
48
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