AEG Electrolux COMPETENCE 5133 V User Manual download pdf (Page 12)

PräklinischeErprobungvonPipeline‐

Substanzen in vitro Modellen

Substanzen



vitro



Modellen

Tumor therapy

in vivo

Tumor model

in vivo

Primary human

tissue culture

tion

Patient

eratio

Analysis (Proliferation, Differentiation, Vascularisation)

onserv

Primary human

ll lt

Tumor therapy

Tumor model

i it

Cryo

ure

n v

tro

Individuelles Thera

iekonze

t für Patienten mit endokrinen Tumoren

www.m4.de

Achievements

•Structuraloutcomes(12/2013):

• CentralizedITstructure:Upgradeanddatatransfertoanew andmorepowerful

databank

If d t

>1000 patients

ti f li i l dt till i

•

orme

consen



rom

>1000



patients



–

ngo

c



as

till

ongo

ng

•Bio‐sampling

:collectioninprogress: 401EDTA,300Plasma,350tumors (12/13)

•

Technology platform

: primary cell cultures, xenograft models

Technology



platform



primary



cell



cultures,



xenograft



models

Investigationaloutcomes(12/2013):

• DualPI3K/mTORinhibitorsarepotentantiproliferativeagentsingastroenteropancreatic

neuroendocrinetumorsandnonfunctioningpituitaryadenomasinvitro

• Clinicalstudyprotocolforthecombinedsomatostatinanalog‐mTORinhibitorforthe

treatmentofaggressivepituitaryadenomasandotherneuroendocrinetumorsfinished

•Developmentofdiagnosticmicroarraysforneuroendocrinetumorsinprogress

•Firstepidemiologicalstudiesonthemetabolicandneuropsychiatric comorbiditiesfinished

www.m4.de

Achievements&Sustainabilit

MedIV+MPI:

•Prospectivefollow‐up examofpatientswithCushing`sdiseasefollowinga

standardized clinical protocol (Interview physical exam MRI biosampling

standardized



clinical



protocol



(Interview

,

physical



exam

,

MRI

,

biosampling

,

questionnairesetc.):178patientsincluded(02/14)

Eit fth t i G i (D d Bli Dü ld f

•

xpans

on

o

ercen

res

n

ermany

nprogress

res

en,

n,

Dü

sse

,

Tübingen)

•Nextstep:Adaptionoftheprotocoltofurtherentitiesofpituitaryadenomas

(Acromegaly,NFPA,Prolactinoma).

•FurtherFunding:

•

Informal request at NAMSE (

Nationalen Aktionsbündnisses für Menschen mit

Informal



request





NAMSE



(

Nationalen



Aktionsbündnisses



für



Menschen



mit



SeltenenErkrankungen)andElse‐Kröner‐Fresenius‐Stiftungforfollow‐up financing

www.m4.de

Vielen Dank für Ihre Aufmerksamkeit !

www.m4.de

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AEG Electrolux COMPETENCE 5133 V User Manual Page 12

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